Open AccessAssociation of H-2 Types with Genetic Control of Immune Responsiveness to IgA Allotypes in the Mouse
Author(s) -
Rose Lieberman,
William Humphrey
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.10.2510
Subject(s) - immune system , biology , locus (genetics) , allele , antibody , gene , immunoglobulin heavy chain , immunoglobulin a , myeloma protein , microbiology and biotechnology , genetics , genetic linkage , immunoglobulin g
The immune response to BALB/c IgA myeloma proteins (Ir-IgA) was determined in mice of various H-2 types from five different linkage groups of immunoglobulin heavy chains (IgCH ). Antisera were examined for antibodies to idiotypic (Fab) and allotypic (Fc) specificities. No immune response to IgA myeloma proteins was found in mice with the same linkage group as BALB/c but with differentH-2 alleles. In mice with immunoglobulin heavy chains that are different than BALB/c, a high immune response to IgA myeloma proteins was found in H-2 types a, k, r, and s; a low response is associated with H-2b and H-2d types. Chromosome mapping ofIr-IgA genes in theH-2 locus indicate that they are on the right side of the chromosome, to the right of theSs locus.Ir-IgA genes are controlled by dominant autosomal genes.