Aurintricarboxylic Acid: Inhibitor of Initiation of Protein Synthesis | Zendy

Margaret L. Stewart | Zendy; Arthur P. Grollman | Zendy; MouTuan Huang | Zendy

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Aurintricarboxylic Acid: Inhibitor of Initiation of Protein Synthesis

Author(s) -

Margaret L. Stewart,

Arthur P. Grollman,

MouTuan Huang

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.1.97

Subject(s) - aurintricarboxylic acid , cycloheximide , protein biosynthesis , ribosome , escherichia coli , biochemistry , protein synthesis inhibitor , chemistry , messenger rna , polynucleotide , microbiology and biotechnology , biology , rna , gene , apoptosis , programmed cell death

Aurintricarboxylic acid prevents the attachment of bacteriophage messenger RNA to ribosomes. As a consequence, initiation of protein synthesis in cell-free extracts prepared from Escherichia coli or rabbit reticulocytes is inhibited at concentrations of dye that do not prevent chain extension. Its properties can be distinguished from other agents that inhibit protein synthesis, including sodium fluoride, cycloheximide, and pactamycin.

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