A Thrombin-Sensitive Protein of Human Platelet Membranes | Zendy

Nancy Lewis Baenziger | Zendy; G. N. Brodie | Zendy; Philip W. Majerus | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Thrombin-Sensitive Protein of Human Platelet Membranes

Author(s) -

Nancy Lewis Baenziger,

G. N. Brodie,

Philip W. Majerus

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.1.240

Subject(s) - thrombin , platelet , membrane , chemistry , membrane protein , biochemistry , polyacrylamide gel electrophoresis , enzyme , biology , immunology

The action of thrombin on intact human platelets has been studied with the aid of polyacrylamide gel electrophoresis in sodium dodecylsulfate. A single major membrane protein band with a molecular weight of 190,000 disappears after thrombin treatment, while a new membrane protein with a molecular weight of 107,000 appears. This may represent hydrolysis of the thrombin-sensitive protein. When platelets are disrupted or when the thrombin-sensitive protein is solubilized from membranes prior to thrombin treatment, no hydrolysis occurs. The effect of thrombin on the platelet membrane protein is complete within 2 min which suggests that hydrolysis of this membrane protein may trigger the physiological effects of thrombin on platelets.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research