Open AccessGenes for Neuronal Properties Expressed in Neuroblastoma × L Cell Hybrids
Author(s) -
John D. Minna,
P. Nelson,
John Peacock,
Devera Glazer,
Marshall W. Nirenberg
Publication year - 1971
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.1.234
Subject(s) - neuroblastoma , hybrid , biology , cell fusion , microbiology and biotechnology , gene , fusion gene , neuron , cell , cell culture , genetics , neuroscience , botany
Neuroblastoma cells with electrically excitable membranes were fused with electrically passive L cells having a hitherto undescribed electrical marker. Hybrid cells, examined 10-40 generations after fusion, were found to be electrically excitable. The results show that at least a part of the genetic information for neuron differentiation can be functionally expressed in N x L hybrid cells. Evidence for the regulation of action potential components was also found.
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