Open AccessRecovery of a New Virus from Apparently Normal Chick Cells by Infection with Avian Tumor Viruses
Author(s) -
Terukiyo Hanafusa,
Hidesaburô Hanafusa,
Tsutomu Miyamoto
Publication year - 1970
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.67.4.1797
Subject(s) - rous sarcoma virus , virus , virology , biology , tumor virus , embryo , avian leukosis , viral transformation , rna , gene , genetics
Cells derived from the majority of chick embryos, although free of presently known avian tumor virus particles, appear to contain genetic materials similar to those found in this virus group. After infection of these cells with avian leukosis or Rous sarcoma virus, the genetic factor was recovered by incorporation into mature infectious virus. The newly isolated virus (RAV-60) did not require the assistance of another virus for its replication. The virus had most of the attributes of an RNA-containing avian leukosis virus, and its outer structure resembled the Rous sarcoma virus known as RSV(0).