Open AccessA Specific Competitive Inhibitor of Angiotensin II
Author(s) -
Garland R. Marshall,
William Vine,
Philip Needleman
Publication year - 1970
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.67.3.1624
Subject(s) - angiotensin ii , peptide , in vivo , chemistry , phenylalanine , in vitro , tyrosine , renin–angiotensin system , pharmacology , peptide synthesis , angiotensin receptor , receptor , biochemistry , medicine , endocrinology , biology , blood pressure , amino acid , microbiology and biotechnology
A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin IIin vitro (isolated rat uterus strips) andin vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds.