Development of Insulin-Sensitivity by Mouse Mammary Gland In Vitro | Zendy

S. H. Friedberg | Zendy; Takami Oka | Zendy; Yale J. Topper | Zendy

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Development of Insulin-Sensitivity by Mouse Mammary Gland In Vitro

Author(s) -

S. H. Friedberg,

Takami Oka,

Yale J. Topper

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.67.3.1493

Subject(s) - insulin , in vitro , medicine , endocrinology , explant culture , mammary gland , biology , insulin sensitivity , insulin resistance , biochemistry , cancer , breast cancer

Explants from mammary gland of pregnant mice are sensitive to insulin, but corresponding explants from mature, virgin mice are insensitive to insulin in certain respects. Isolated virgin tissue can acquire insulin-sensitivity independent of exogenous insulin. Some endocrinological and developmental implications are discussed.

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