Absence of a Cell Membrane Alteration Function in Non-transforming Mutants of Polyoma Virus | Zendy

Thomas L. Benjamin | Zendy; Max M. Burger | Zendy

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Absence of a Cell Membrane Alteration Function in Non-transforming Mutants of Polyoma Virus

Author(s) -

Thomas L. Benjamin,

Max M. Burger

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.67.2.929

Subject(s) - lytic cycle , virus , mutant , biology , transformation (genetics) , polyoma virus , virology , viral transformation , receptor , cell , dna , microbiology and biotechnology , gene , biochemistry

A surface receptor for an agglutinin, exposed in transformed but not in normal cells, arises in normal mouse cells during lytic infection by polyoma virus. The structural change in the surface membrane characteristic of transformed cells and of cells productively infected by wild type virus fails to occur in normal mouse cells infected by mutants of the virus that are unable to cause transformation. The exposure of the receptor site by wild type virus is reversibly blocked by inhibitors of DNA synthesis.

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