Kinetic Model of Conduction Changes across Excitable Membranes | Zendy

Mahendra Kumar Jain | Zendy; Richard H.L. Marks | Zendy; Eugene H. Cordes | Zendy

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Kinetic Model of Conduction Changes across Excitable Membranes

Author(s) -

Mahendra Kumar Jain,

Richard H.L. Marks,

Eugene H. Cordes

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.67.2.799

Subject(s) - membrane , thermal conduction , membrane potential , biophysics , population , current (fluid) , chemistry , biological system , kinetic energy , chemical physics , biology , physics , thermodynamics , biochemistry , classical mechanics , medicine , environmental health

A kinetic model describing conduction changes across excitable membranes is proposed. It assumes that a population of discrete membrane sites is distributed among several distinct functional states determined by the voltage across the membrane. Interconversion of these states is postulated to occur by first-order reactions. It provides a satisfactory description of the central aspects of excitable membrane behavior, including current-time and current-voltage relationships, action potential, and effects of inhibitors.

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