Regulation of Acetylcholinesterase in Neuroblastoma Cells | Zendy

Alfred Blume | Zendy; Florence B. Gilbert | Zendy; Samuel H. Wilson | Zendy; J L Farber | Zendy; Roger N. Rosenberg | Zendy; Marshall W. Nirenberg | Zendy

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Regulation of Acetylcholinesterase in Neuroblastoma Cells

Author(s) -

Alfred Blume,

Florence B. Gilbert,

Samuel H. Wilson,

J L Farber,

Roger N. Rosenberg,

Marshall W. Nirenberg

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.67.2.786

Subject(s) - acetylcholinesterase , neuroblastoma , cell division , cell , cell growth , enzyme , chemistry , biology , cell culture , microbiology and biotechnology , biochemistry , genetics

The specific activity of mouse neuroblastoma acetylcholinesterase (EC 3.1.1.7) increased 25-fold when the rate of cell division was restricted. The results show that acetylcholinesterase activity is regulated in neuroblastoma cells and that the regulatory mechanism is inversely related to the rate of cell division. Under the same conditions the specific activity of catechol-O-methyl transferase (EC 2.1.1.6) did not change significantly.

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