Open AccessRegulation of Cellular Interferon Production: Enhancement by Antimetabolites
Author(s) -
Yadi Tan,
John A. Armstrong,
Yang Ke,
Monto Ho
Publication year - 1970
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.67.1.464
Subject(s) - cycloheximide , newcastle disease , interferon , protein biosynthesis , dactinomycin , chemistry , cell culture , cell , biology , biochemistry , virus , virology , genetics
Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.
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