Precipitation of Proteins by Vinblastine and Calcium Ions | Zendy

L Wilson | Zendy; Joseph Bryan | Zendy; A. Ruby | Zendy; Daniel Mazia | Zendy

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Precipitation of Proteins by Vinblastine and Calcium Ions

Author(s) -

L Wilson,

Joseph Bryan,

A. Ruby,

Daniel Mazia

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.66.3.807

Subject(s) - vinblastine , precipitation , ion , sulfate , calcium , chemistry , tubulin , biochemistry , inorganic chemistry , microtubule , biophysics , biology , microbiology and biotechnology , organic chemistry , physics , genetics , chemotherapy , meteorology

We have found that vinblastine sulfate can precipitate a number of proteins in addition to microtubule protein. Those proteins which precipitate with vinblastine sulfate, all of which were derived from structure, also precipitate with Ca(2+) ions. Our results suggest that vinblastine sulfate, presumably acting as a cation, precipitates proteins by combining with sites which can also combine with Ca(2+) ions.

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