A Variable Region Subclass of Heavy Chains Common to Immunoglobulins G, A, and M and Characterized by an Unblocked Amino-Terminal Residue | Zendy

A. C. Wang | Zendy; J. R. L. Pink | Zendy; H. Hugh Fudenberg | Zendy; J.I. Ohms | Zendy

Open Access

A Variable Region Subclass of Heavy Chains Common to Immunoglobulins G, A, and M and Characterized by an Unblocked Amino-Terminal Residue

Author(s) -

A. C. Wang,

J. R. L. Pink,

H. Hugh Fudenberg,

J.I. Ohms

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.66.3.657

Subject(s) - subclass , residue (chemistry) , immunoglobulin heavy chain , heavy chain , antibody , chemistry , amino acid , peptide sequence , immunoglobulin light chain , sequence (biology) , stereochemistry , alanine , chain (unit) , combinatorics , biochemistry , mathematics , biology , genetics , physics , gene , astronomy

Heavy chains of IgG, IgA, and IgM classes of human immunoglobulins were compared by N-terminal residue determination and partial amino acid sequence analysis. A third subclass of the variable region of heavy chains was observed; an unblocked glutamic acid as the N-terminal residue is characteristic of this subclass. Our results indicated that the heavy chain variable region subclasses are not class specific, and that a given heavy chain variable region may be found in association with constant regions for mu-chains, alpha-chains, or gamma-chains of various subclasses.

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