Open AccessImplications of TL Phenotype Changes in an H-2-Loss Variant of a Transplanted H-2 b /H-2 a Leukemia
Author(s) -
Edward A. Boyse,
Elisabeth Stockert,
Chika A. Iritani,
Lloyd J. Old
Publication year - 1970
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.65.4.933
Subject(s) - phenotype , leukemia , microbiology and biotechnology , chemistry , biology , genetics , gene
An H-2-loss variant line, lacking H-2(a) antigens, was obtained from an H-2(b)/H-2(a) (C57BL x A)F(1) transplanted leukemia by immunoselection. The TL phenotype of the unselected line was TL.1,2,3,4 and that of the variant TL.1,2,4, which is the phenotype of TL(+) leukemias of C57BL. This finding, and the observed quantitative alterations of antigens TL.1,2 and 4, indicate that the Tla (Thymus leukemia antigen) locus was functionally deleted together with the H-2 locus in the process of variant formation, despite absence of selection against cells carrying TL antigens. Representation of H-2 antigens of the remaining haplotype, H-2(b), was quantitatively unchanged.