Open AccessSV40-Specific RNA in the Nucleus and Polyribosomes of Transformed Cells
Author(s) -
Uno Lindberg,
James Darnell
Publication year - 1970
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.65.4.1089
Subject(s) - polysome , rna , cytoplasm , biology , messenger rna , cell nucleus , dna , microbiology and biotechnology , nucleus , virus , virology , biochemistry , ribosome , gene
Cells transformed by the oncogenic virus SV40 are known to contain viral DNA integrated into cellular DNA and to produce virus-specific RNA. It has been shown that nuclear molecules containing virus-specific sequences are considerably longer than presumed virus-specific mRNA molecules from cytoplasmic polyribosomes. This finding suggests the possibility that cytoplasmic mRNA is derived by the specific cleavage of larger nuclear RNA.