Open AccessCellular Sites of Immunologic Unresponsiveness
Author(s) -
Jacques M. Chiller,
Gail S. Habicht,
William O. Weigle
Publication year - 1970
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.65.3.551
Subject(s) - bone marrow , immunology , immune system , immunologic tolerance , biology , immune tolerance , chemistry
The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.
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