Mechanism of Action of 2-Mercapto-1(β-4-pyridethyl)benzimidazole: A Reversible Inhibitor of Interferon Activity | Zendy

Robert M. Friedman | Zendy; Ira Pastan | Zendy

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Mechanism of Action of 2-Mercapto-1(β-4-pyridethyl)benzimidazole: A Reversible Inhibitor of Interferon Activity

Author(s) -

Robert M. Friedman,

Ira Pastan

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.65.1.104

Subject(s) - interferon , mechanism of action , benzimidazole , chemistry , rna , phospholipid , protein biosynthesis , biochemistry , biology , microbiology and biotechnology , in vitro , virology , gene , organic chemistry , membrane

2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.

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