Open AccessAM(1), THE FIRST GENETIC MARKER OF HUMAN IMMUNOGLOBULIN A
Author(s) -
Girish N. Vyas,
H. Hugh Fudenberg
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.64.4.1211
Subject(s) - mendelian inheritance , biology , genetics , antibody , subclass , genetic marker , population , allele , polymorphism (computer science) , gene , immunology , medicine , environmental health
The genetic markers of human immunoglobulins have significantly contributed to the understanding of the molecular biology of antibody synthesis. Like the Gm markers of IgG, the first genetic marker of serum IgA, a major immunoglubulin of exocrine secretions, has now been defined and termed Am(1). It is inherited as a Mendelian dominant trait and is independent of the Gm and Inv allotypes. Am(1) is localized in the α-chains of the γA2 subclass and is independent of the serum γA2 levels. Its polymorphism makes it suitable for studies in population genetics and the molecular biology of IgA globulin.