CROSS-BRIDGE PROPERTIES DERIVED FROM MUSCLE ISOTONIC VELOCITY TRANSIENTS | Zendy

Richard J. Podolsky | Zendy; A. C. Nolan | Zendy; S. A. Zaveler | Zendy

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CROSS-BRIDGE PROPERTIES DERIVED FROM MUSCLE ISOTONIC VELOCITY TRANSIENTS

Author(s) -

Richard J. Podolsky,

A. C. Nolan,

S. A. Zaveler

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.64.2.504

Subject(s) - protein filament , myosin , biophysics , actin , contraction (grammar) , isotonic , muscle contraction , myosin head , chemistry , projection (relational algebra) , physics , mechanics , anatomy , biology , mathematics , myosin light chain kinase , biochemistry , medicine , algorithm , endocrinology

The rate constants for the turnover of cross-bridges during frog muscle contraction were determined from an analysis of the motion that follows step decreases in load. For a given projection from the myosin filament, there appears to be a range of about 100 A along the length of the filament over which the projection can attach to the actin filament and form a cross-bridge. The site of attachment is then displaced by a distance of this same order before the link is broken. The values of the rate constants also imply that a cross-bridge is formed each time an actin site comes within range of a myosin projection, so that the turnover of cross-bridges for a given contraction distance is independent of the speed of the motion.

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