Open AccessCELLS INVOLVED IN THE IMMUNE RESPONSE, XIII. THE NATURE OF THE CELLULAR INTERACTIONS RELATING ANTIBODY FORMATION AND IMMUNOLOGIC TOLERANCE: A UNIFIED HYPOTHESIS
Author(s) -
M. Richter
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.64.1.75
Subject(s) - immune system , biology , antibody , immunology , antibody response , humoral immunity , microbiology and biotechnology , immunologic tolerance , immune tolerance , cellular immunity
The various cells and cell pathways involved in the induction of the primary humoral immune response have been discussed from the point of view of the unitary, as opposed to the multiple, pathway concept. The immunocompetent cells made unresponsive in the immunologically tolerant animal and the cells capable of responding with antibody formation were considered. It is concluded that there exist multiple cellular pathways through which the humoral immune response may be expressed.