Open AccessAGING OF α-CRYSTALLINS DURING DEVELOPMENT OF THE LENS
Author(s) -
Winifred G. Palmer,
John Papaconstantinou
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.64.1.404
Subject(s) - protein subunit , lens (geology) , crystallin , chemistry , g alpha subunit , biochemistry , biology , paleontology , gene
Fetal α-crystallin from the bovine lens can be resolved into three major subunit fractions by ion exchange chromatography. A fourth subunit gradually arises during the development of the lens. Incorporation studies indicate that this subunit is not formed byde novo synthesis but by the chemical conversion of one subunit into another. Possible mechanisms for this conversion are discussed.