Open AccessMECHANISM OF PROFLAVIN MUTAGENESIS
Author(s) -
Anand Sarabhai,
Hildegard Lamfrom
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.63.4.1196
Subject(s) - dna ligase , mutagenesis , biology , genetics , dna , dna ligases , bacteriophage , mechanism (biology) , dna replication , mutation , microbiology and biotechnology , escherichia coli , gene , physics , quantum mechanics
The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.