MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTURE | Zendy

Václav Klement | Zendy; Wallace P. Rowe | Zendy; Janet W. Hartley | Zendy; Wendell E. Pugh | Zendy

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MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTURE

Author(s) -

Václav Klement,

Wallace P. Rowe,

Janet W. Hartley,

Wendell E. Pugh

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.3.753

Subject(s) - tissue culture , syncytium , rous sarcoma virus , biology , leukemia , virology , cell culture , murine leukemia virus , embryo , virus , in vitro , microbiology and biotechnology , immunology , biochemistry , genetics

Tissue culture cells of a Rous virus-induced rat tumor undergo syncytium formation when placed in contact with mouse embryo cell cultures infected with murine leukemia viruses. This phenomenon can be used as a cytopathic end point for isolating and titrating these viruses in tissue culture. The principle should be applicable to detection of leukemia viruses of other species.

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