Open AccessVITAMIN D 3 -STIMULATED TEMPLATE ACTIVITY OF CHROMATIN FROM RAT INTESTINE
Author(s) -
Richard B. Hallick,
Hector F. DeLuca
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.63.2.528
Subject(s) - chromatin , histone , chemistry , microbiology and biotechnology , biochemistry , biology , computational biology , dna
Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D3 is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.