z-logo
open-access-imgOpen Access
VITAMIN D 3 -STIMULATED TEMPLATE ACTIVITY OF CHROMATIN FROM RAT INTESTINE
Author(s) -
Richard B. Hallick,
Hector F. DeLuca
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.63.2.528
Subject(s) - chromatin , histone , chemistry , microbiology and biotechnology , biochemistry , biology , computational biology , dna
Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D3 is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here