VITAMIN D 3 -STIMULATED TEMPLATE ACTIVITY OF CHROMATIN FROM RAT INTESTINE | Zendy

Richard B. Hallick | Zendy; Hector F. DeLuca | Zendy

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VITAMIN D ₃ -STIMULATED TEMPLATE ACTIVITY OF CHROMATIN FROM RAT INTESTINE

Author(s) -

Richard B. Hallick,

Hector F. DeLuca

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.2.528

Subject(s) - chromatin , histone , chemistry , microbiology and biotechnology , biochemistry , biology , computational biology , dna

Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D3 is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.

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