A MUSCARONE-BINDING MATERIAL IN ELECTROPLAX AND ITS RELATION TO THE ACETYLCHOLINE RECEPTOR, I. CENTRIFUGAL ASSAY | Zendy

R. D. O’Brien | Zendy; L. P. Gilmour | Zendy

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A MUSCARONE-BINDING MATERIAL IN ELECTROPLAX AND ITS RELATION TO THE ACETYLCHOLINE RECEPTOR, I. CENTRIFUGAL ASSAY

Author(s) -

R. D. O’Brien,

L. P. Gilmour

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.2.496

Subject(s) - acetylcholine , acetylcholine receptor , torpedo , chemistry , curare , acetylcholinesterase , biophysics , receptor , stereochemistry , biochemistry , enzyme , pharmacology , biology

A muscarone-binding material has been found inTorpedo electroplax. The material behaves in several ways as one would expect of the binding component of the acetylcholine receptor, especially in its high affinity for muscarone (approximateK = 7 × 10-6 M ), acetylcholine (approximateK = 1.1 × 10-6 M ), curare, and nicotine, and its insensitivity to noncholinergic agents; the reversibility of its muscarone binding; and its suitably small amount (about 1.8 nmole/gm). The material appears not to be acetylcholinesterase.

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