RECESSIVE LETHALS: A NEW CLASS OF NONSENSE SUPPRESSORS IN Escherichia coli | Zendy

Larry Soll | Zendy; Paul Berg | Zendy

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RECESSIVE LETHALS: A NEW CLASS OF NONSENSE SUPPRESSORS IN Escherichia coli

Author(s) -

Larry Soll,

Paul Berg

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.2.392

Subject(s) - suppressor , escherichia coli , biology , genetics , nonsense , heterozygote advantage , allele , nonsense mutation , mutation , microbiology and biotechnology , gene , missense mutation

Two new nonsense suppressors inEscherichia coli were found in partial diploids carrying F′14 and were shown to be on the episome. These suppressors can exist only in cells which also contain thesu - allele, i.e.,su + /su - heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal.Su 7, an amber suppressor, has an efficiency of 76 per cent andsu 8, an ochre suppressor, an efficiency of 4 per cent.

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