Open AccessSURFACE-SPECIFIC CHARACTERISTICS OF A CONTACT-INHIBITED CELL LINE CONTAINING THE SV40 VIRAL GENOME
Author(s) -
Robert Pollack,
Max M. Burger
Publication year - 1969
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.62.4.1074
Subject(s) - cell culture , contact inhibition , trypsin , microbiology and biotechnology , biology , fibroblast , cell , saturation (graph theory) , virology , virus , chemistry , biochemistry , enzyme , genetics , mathematics , combinatorics
A cytoagglutinin purified from wheat germ lipase agglutinated five related murine fibroblast cell lines in the order of their saturation densities. One cell line, which was transformed by the oncogenic papova virus SV40 but which had a low saturation density, agglutinated poorly. Preincubation of cells with trypsin increased their agglutinability, but trypsin made no cell line more agglutinable than the cell line with the highest saturation density.
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