ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES | Zendy

JeanPierre Changeux | Zendy; Jean Paul Thiery | Zendy; Yvonne Tung | Zendy; C. Kittel | Zendy

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ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

Author(s) -

JeanPierre Changeux,

Jean Paul Thiery,

Yvonne Tung,

C. Kittel

Publication year - 1967

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.57.2.335

Subject(s) - adaptation (eye) , climate change , sustainability , cooperativity , macro , management science , environmental resource management , environmental ethics , computer science , political science , ecology , economics , psychology , biology , philosophy , neuroscience , programming language , biochemistry

: We extend the Monod-Wyman-Changeux of allosteric transitions in enzyme-substrate reactions to a membrane composed of identical units (protomers). It is supposed that each protomer can exist in two states. The interaction between protomers is treated in the molecular field approximation. It appears possible to have a first-order phase transition when the chemical potential of the substrate is varied, holding the temperature constant. The wide range of possible biological implications is discussed. (Author)

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