CHROMOSOME STRUCTURE IN PHAGE T4, III. TERMINAL REDUNDANCY AND LENGTH DETERMINATION | Zendy

George Streisinger | Zendy; Joyce Emrich | Zendy; Mary M. Stahl | Zendy

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CHROMOSOME STRUCTURE IN PHAGE T4, III. TERMINAL REDUNDANCY AND LENGTH DETERMINATION

Author(s) -

George Streisinger,

Joyce Emrich,

Mary M. Stahl

Publication year - 1967

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.57.2.292

Subject(s) - induced pluripotent stem cell , drug discovery , cardiac electrophysiology , stem cell , myocyte , biology , computational biology , microbiology and biotechnology , in vitro , cell , biophysics , electrophysiology , neuroscience , bioinformatics , genetics , embryonic stem cell , gene

In previous communications it was suggested that chromosomes of phage T4 are circularly permuted and terminally redundant.1 2 Heterozygotes formed by deletion ri mutants and r+, and by the host range alleles hI+ and h4±, were shown to behave as if they were due to this terminal redundancy.2 After infection and replication the chromosome of any one phage particle is assumed to become circularly permuted so that the genetic location of the beginning of any one progeny chromosome is randomly distributed over the genome. This could take place through the formation of recombinants by whole chromosomes or by fragments of chromosomes:

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