Purine binding to dinucleotides: evidence for base stacking and insertion. | Zendy

NeiLi Chan | Zendy; Benedict W. Bangerter | Zendy; Peter Horton | Zendy

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Purine binding to dinucleotides: evidence for base stacking and insertion.

Author(s) -

NeiLi Chan,

Benedict W. Bangerter,

Peter Horton

Publication year - 1966

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.55.4.720

Subject(s) - stacking , purine , base (topology) , chemistry , nucleotide , stereochemistry , biochemistry , mathematics , enzyme , organic chemistry , gene , mathematical analysis

In an effort to understand the factors which may contribute to the stabilization of nucleic acids as well as the basic mechanism of the recognition process involved in the enzymatic replication of nucleic acids in vitro, we have embarked upon a systematic study of the interaction of biological bases and nucleosides with simple oligonucleotides by proton magnetic resonance. We wish to report here results which we have obtained on the interaction of purine with the following 3' --> 5'-dinucleotides: TpT, TpdU, and dUpT (T = thymidine, dU = 2'-deoxyuridine).

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