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2 Gierer, A., and G. Schramm, Nature, 177, 702 (1956). 3 Gierer, A., and G. Schramm, Z. Naturforsch., lIb, 138 (1956). 4 Northrop,T. G., and R. L. Sinsheimer, J. Chem. Phys., 22, 703 (1954). c Fraenkel-Conrat, H., B. Singer, and R. C. Williams, Biochim. Biophys. Acta, 25, 87 (1957). 6 Gierer, A., Nature, 179, 1297 (1957). 7Gierer, A., Z. Naturforsch., 13b, 485 (1958). 8 Ginoza, W., and A. Norman, Nature, 179, 520 (1957). 9 Pirie, N. W., N.Y. Acad. Sci. Spec. Publ., V, 247 (1957). 10 Bawden, F. C., and N. W. Pirie, J. Gen. Microbiol., 17,80 (1957). 1 Fraenkel-Conrat, H., N.Y. Acad. Sci. Spec. Publ., V, 219 (1957). 12 Gierer, A., Z.Naturforsch., 13b, 477 (1958). 13 Montroll, E. W., and R. Simha, J. Chem. Phys., 8, 721 (1940). 14 Fresco, J. R., and P. Doty, J. Am. Chem. Soc., 79, 3928 (1957). 15 This pattern of degradation bears obvious resemblance to the pattern of degradation observed with microsomes.16'-8 This pattern may also provide an explanation for the repeated19-2' indications of preferred points of cleavage of theTMV rods. "6 Ts'o, P. 0. P. in Microsomal Particles and Protein Synthesis, pp. 156-168, publ. by Washington Acad. Sci., Washington, D.C. (1958). 17 Chao, F. C., Arch. Biochem. Biophys., 70, 426 (1957). 8 Tissieres, A., and J. D. Watson, Nature, 182, 778 (1958). 19 Schramm, G., G. Schumacher, and W. Zillig, Z. Naturforsch., lOb, 481 (1955). 20 Harrington, W. F., and H. K. Schachman, Arch. Biochem. Biophys., 65, 278 (1956). 21 Chao, F. C., Abst. ACS Meeting, Chicago, Illinois, Sept. 7-12 (1958), p. 286. 22 Yphantis, D. A., and D. F. Waugh, J. Phys. Chem., 60, 623, 630 (1956). 23 We are indebted to Dr. W. Takahashi for a supply of seeds of the Xanthi strain.

TWO CONFIGURATIONS OF TOBACCO MOSAIC VIRUS-RIBONUCLEIC ACID