Open AccessShort-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
Author(s) -
Ye Xiong,
Naokazu Miyamoto,
Kenji Shibata,
Mark A. Valasek,
Toshiyuki Motoike,
Rafal M. Kedzierski,
Masashi Yanagisawa
Publication year - 2004
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2637002100
Subject(s) - leptin , adipose tissue , leptin receptor , endocrinology , medicine , adipocyte , energy homeostasis , adipokine , receptor , biology , chemistry , obesity
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.