Open AccessHuman herpesvirus diversity is altered in HLA class I binding peptides
Author(s) -
William Palmer,
Marco Telford,
Arcadi Navarro,
Gabriel Santpere,
Paul J. Norman
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2123248119
Subject(s) - human leukocyte antigen , biology , virus , immune system , virology , coevolution , immunology , genetics , antigen , evolutionary biology
Significance Viruses evolve to evade immune recognition that may otherwise limit transmission. Presentation of virus peptides by human leukocyte antigen (HLA) class I is a necessary step in the recognition of infection by immune cells. Virus adaptation to evade this immune recognition has not been formally tested across the diversity of HLA class I allotypes and virus strains. We analyzed genetic diversity of three human herpesviruses across peptides that bind diverse HLA class I allotypes. We find that adaptation to evade HLA class I recognition may be a general phenomenon shaping human herpesvirus genetic diversity, particularly for those proteins expressed during viral latency. This broad scope, across human and virus diversity, provides a unique comparative perspective of human–herpesvirus coevolution.