Regulation of NMDA receptors by cyclin-dependent kinase-5 | Zendy

Bingsheng Li | Zendy; MiaoKun Sun | Zendy; Lei Zhang | Zendy; Satoru Takahashi | Zendy; Wu Ma | Zendy; Lúcia Vinadé | Zendy; Ashok B. Kulkarni | Zendy; Roscoe O. Brady | Zendy; Harish C. Pant | Zendy

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Regulation of NMDA receptors by cyclin-dependent kinase-5

Author(s) -

Bingsheng Li,

MiaoKun Sun,

Lei Zhang,

Satoru Takahashi,

Wu Ma,

Lúcia Vinadé,

Ashok B. Kulkarni,

Roscoe O. Brady,

Harish C. Pant

Publication year - 2001

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.211428098

Subject(s) - long term potentiation , nmda receptor , synaptic plasticity , cyclin dependent kinase 5 , neuroscience , microbiology and biotechnology , biology , neurotransmission , kinase , long term depression , glutamate receptor , chemistry , biochemistry , receptor , protein kinase a , ampa receptor , mitogen activated protein kinase kinase

Members of the N-methyl-d-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system. NMDARs are phosphorylated by both serine/threonine and tyrosine kinases. Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells. Moreover, we show that roscovitine, a selective Cdk5 inhibitor, blocks both long-term potentiation induction and NMDA-evoked currents in rat CA1 hippocampal neurons. These results suggest that Cdk5 plays a key role in synaptic transmission and plasticity through its up-regulation of NMDARs.

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