Open AccessThe E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms
Author(s) -
Jongbin Lee,
Chunghun Lim,
Tae Hee Han,
Tomas Andreani,
Matthew Moye,
Jack Curran,
E. M. Johnson,
William L. Kath,
Casey O. Diekman,
Bridget C. Lear,
Ravi Allada
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2110767118
Subject(s) - biology , ubiquitin ligase , microbiology and biotechnology , circadian rhythm , timeless , suprachiasmatic nucleus , neuropeptide , circadian clock , neuroscience , clock , ubiquitin , genetics , gene , receptor
Significance In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene,Tango10 , critical for daily behavioral rhythms. TANGO10 functions as an adaptor with its partner, the E3 ubiquitin ligase CULLIN 3, to regulate protein ubiquitination, neuronal excitability via voltage-gated potassium channels, and neuropeptide accumulation. These studies define a mechanism for control of neuronal excitability and daily rhythmicity.