Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability | Zendy

Li He | Zendy; Cheng Zhao | Zendy; Qingzhu Zhang | Zendy; Gaurav Zinta | Zendy; Dong Wang | Zendy; Rosa LozanoDurán | Zendy; JianKang Zhu | Zendy

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Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability

Author(s) -

Li He,

Cheng Zhao,

Qingzhu Zhang,

Gaurav Zinta,

Dong Wang,

Rosa LozanoDurán,

JianKang Zhu

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2107320118

Subject(s) - dna methylation , rna directed dna methylation , transposable element , biology , chromatin , methylation , genetics , dna , microbiology and biotechnology , genome , gene , gene expression

Significance In plants, several DNA methylation pathways help maintain DNA methylation patterns to ensure that transposons remain in a silenced state and cell-specific DNA methylation is preserved after cell division. Here, we demonstrate that loss of function of the chromatin remodeler DDM1 induces a pathway conversion from CMT2- to RdDM-dependency to ensure the maintenance of CHH methylation. In plants defective in both DDM1 and RdDM, there is strong reactivation of TEs and a burst of TE transposition. Thus, our work not only identifies a variant of the RdDM pathway, but also shows that DNA methylation maintenance at a given locus is an adaptable process, revealing the existence of a double-insurance mechanism for the regulation of DNA methylation to guarantee genome integrity.

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