Open AccessLipid droplets in mammalian eggs are utilized during embryonic diapause
Author(s) -
Roberta Arena,
Simona Bisogno,
Łukasz Gąsior,
Joanna Rudnicka,
Laura Bernhardt,
Thomas Haaf,
Federica Zacchini,
M. Bochenek,
Kinga Fic,
Ewelina Bik,
Małgorzata Barańśka,
Anna BodzońKułakowska,
Piotr Suder,
Joanna Depciuch,
Artur Gurgul,
Zbigniew Polański,
Grazyna Ptak
Publication year - 2021
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2018362118
Subject(s) - embryo , embryonic stem cell , biology , diapause , lipid droplet , microbiology and biotechnology , embryogenesis , lipid metabolism , catabolism , endocrinology , metabolism , biochemistry , botany , gene , larva
Significance Lipid droplets (LDs) are stored in the embryo throughout the preimplantation development. Yet, the role of LDs in the embryo remains unknown. Embryonic diapause (ED) is a temporary arrest of an embryo when it waits for the uterine receptivity signal to implant. We provide evidence that LDs play a crucial role in maintaining ED. Diapausing embryos exhibit increased release of exosomes reflecting elevated embryonic signaling to the mother. During ED, the decrease in lipid is caused by a switch from carbohydrate metabolism to lipid catabolism. We have also shown that presence of LDs in the oocytes of various mammals positively corelates with their species-specific length of diapause. Our results reveal the functional role of LDs in embryonic development.
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