English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Cholesteryl-α-D-glucopyranoside (CGL) is a cell wall constituent ofHelicobacter pylori . It is synthesized by cholesterol α-glucosyltransferase, which transfers glucose from UDP-glucose to a carbon atom at the third position of cholesterol with an α1,3-linkage. We previously discovered that αGlcNAc contained in gastric gland mucins serves as antibiotic againstH. pylori by inhibiting CGL biosynthesis. Here, we reveal that cholestenone exhibits antibiotic activity againstH. pylori including a clarithromycin-resistantH. pylori strain by suppressing CGL biosynthesis in vitro. Strikingly, oral administration of cholestenone alone successfully eradicatedH. pylori infection in C57BL/6 mice. Given its safety, cholestenone therapy could be promising to eradicateH. pylori , including antibiotic-resistant strains.

Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL