Open AccessAn in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease
Author(s) -
Adonis D’Mello,
Ashleigh N. Riegler,
Eriel Martínez,
Sarah M. Beno,
Tiffany D. Ricketts,
Ellen F. Foxman,
Carlos J. Orihuela,
Hervé Tettelin
Publication year - 2020
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2010428117
Subject(s) - biology , host (biology) , pathogen , streptococcus pneumoniae , colonization , transcriptome , gene expression , gene , microbiology and biotechnology , pathogenesis , host–pathogen interaction , disease , genetics , immunology , bacteria , virulence , medicine , pathology
Significance We detail host–pathogen interaction gene-expression profiles ofStreptococcus pneumoniae (Spn ) and its infected host at disease relevant anatomical sites using mice as experimental models. We identify the shared and organ-specific transcriptomes ofSpn , show that bacterial and host gene-expression profiles are highly distinct during asymptomatic colonization versus disease-causing infection, and demonstrate thatSpn and host genes with high levels of expression contribute to pathogenesis or host defense, respectively, making them optimal targets for intervention.