Open AccessGATA6 is a regulator of sinus node development and heart rhythm
Author(s) -
Lara Gharibeh,
Abir Yamak,
Jamieson Whitcomb,
Aizhu Lu,
Mathieu Joyal,
Hiba Komati,
Wenbin Liang,
Céline Fiset,
Moemer
Publication year - 2020
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2007322118
Subject(s) - gata6 , regulator , sinoatrial node , haploinsufficiency , biology , genetics , transcription factor , phenotype , endocrinology , gene , heart rate , blood pressure
Significance GATA6 is a key regulator of sinus node (SAN) development. Loss of oneGata6 allele disrupts patterning and size of the SAN. GATA6 plays cell autonomous as well as non-cell autonomous functions in several cell types required for proper SAN development and function. Haploinsufficiency ofGata6 in mice leads to electrophysiological alterations and increases susceptibility to develop arrhythmias. GATA6 is critical for pacemaker cell differentiation and cardiac conduction.