CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation | Zendy

Jingmei Hsu | Zendy; Hsuan-Ting Huang | Zendy; Chung-Tsai Lee | Zendy; Avik Choudhuri | Zendy; Nicola K. Wilson | Zendy; Brian J. Abraham | Zendy; Victoria Moignard | Zendy; Iwo Kuciński | Zendy; Shuqian Yu | Zendy; R. Katherine Hyde | Zendy; Joanna Tober | Zendy; Xiongwei Cai | Zendy; Yan Li | Zendy; Yalin Guo | Zendy; Song Yang | Zendy; Michael Superdock | Zendy; Eirini Trompouki | Zendy; Fernando J. CaleroNieto | Zendy; Alireza Ghamari | Zendy; Jing Jiang | Zendy; Peng Gao | Zendy; Long Gao | Zendy; Vy Nguyen | Zendy; Anne L. Robertson | Zendy; Ellen M. Durand | Zendy; Katie L. Kathrein | Zendy; Iannis Aifantis | Zendy; Scott A. Gerber | Zendy; Wei Tong | Zendy; Kai Tan | Zendy; Alan Cantor | Zendy; Yi Zhou | Zendy; Peiqing Liu | Zendy; Richard A. Young | Zendy; Berthold Göttgens | Zendy; Nancy A. Speck | Zendy; Leonard I. Zon | Zendy

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CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

Author(s) -

Jingmei Hsu,

Hsuan-Ting Huang,

Chung-Tsai Lee,

Avik Choudhuri,

Nicola K. Wilson,

Brian J. Abraham,

Victoria Moignard,

Iwo Kuciński,

Shuqian Yu,

R. Katherine Hyde,

Joanna Tober,

Xiongwei Cai,

Yan Li,

Yalin Guo,

Song Yang,

Michael Superdock,

Eirini Trompouki,

Fernando J. CaleroNieto,

Alireza Ghamari,

Jing Jiang,

Peng Gao,

Long Gao,

Vy Nguyen,

Anne L. Robertson,

Ellen M. Durand,

Katie L. Kathrein,

Iannis Aifantis,

Scott A. Gerber,

Wei Tong,

Kai Tan,

Alan Cantor,

Yi Zhou,

Peiqing Liu,

Richard A. Young,

Berthold Göttgens,

Nancy A. Speck,

Leonard I. Zon

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2003228117

Subject(s) - gene knockdown , zebrafish , haematopoiesis , microbiology and biotechnology , chromatin , biology , cellular differentiation , gene , genetics , stem cell

Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation. Binding motifs for RUNX and other hematopoietic transcription factors are enriched at sites occupied by CHD7, and decreased RUNX1 occupancy correlated with loss of CHD7 localization. CHD7 physically interacts with RUNX1 and suppresses RUNX1-induced expansion of HSPCs during development through modulation of RUNX1 activity. Consequently, the RUNX1:CHD7 axis provides proper timing and function of HSPCs as they emerge during hematopoietic development or mature in adults, representing a distinct and evolutionarily conserved control mechanism to ensure accurate hematopoietic lineage differentiation.

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