Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function | Zendy

Anvay Ukidve | Zendy; Zongmin Zhao | Zendy; Alexandra Fehnel | Zendy; Vinu Krishnan | Zendy; Daniel C. Pan | Zendy; Yongsheng Gao | Zendy; Abhirup Mandal | Zendy; Vladimir R. Muzykantov | Zendy; Samir Mitragotri | Zendy

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Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function

Author(s) -

Anvay Ukidve,

Zongmin Zhao,

Alexandra Fehnel,

Vinu Krishnan,

Daniel C. Pan,

Yongsheng Gao,

Abhirup Mandal,

Vladimir R. Muzykantov,

Samir Mitragotri

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2002880117

Subject(s) - immunization , immune system , spleen , innate immune system , immunology , vaccination , antigen , function (biology) , biology , microbiology and biotechnology

Significance Red blood cells perform the unique function of capturing certain pathogens in blood and presenting them to the immune cells in the spleen. We developed a strategy based on this innate immune function of red blood cells to deliver vaccine nanoparticles to the spleen. This biomimetic strategy induced a strong vaccination response without the need for foreign adjuvants.

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