Preventing presbycusis in mice with enhanced medial olivocochlear feedback | Zendy

Luis E. Boero | Zendy; Valeria C. Castagna | Zendy; Gonzalo Terreros | Zendy; Marcelo J. Moglie | Zendy; Sebastián Silva | Zendy; Juan C. Maass | Zendy; Paul Fuchs | Zendy; Paul H. Délano | Zendy; Ana Belén Elgoyhen | Zendy; María Eugenia GómezCasati | Zendy

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Preventing presbycusis in mice with enhanced medial olivocochlear feedback

Author(s) -

Luis E. Boero,

Valeria C. Castagna,

Gonzalo Terreros,

Marcelo J. Moglie,

Sebastián Silva,

Juan C. Maass,

Paul Fuchs,

Paul H. Délano,

Ana Belén Elgoyhen,

María Eugenia GómezCasati

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2000760117

Subject(s) - presbycusis , hearing loss , audiology , noise induced hearing loss , cochlea , medicine , otoacoustic emission , outer hair cells , neuroscience , noise exposure , psychology

Significance Age-related hearing loss is the most common cause of hearing loss. Here, we show that medial olivocochlear feedback mediates resistance to age-related hearing loss—presbycusis—and that this occurs via the α9α10 cholinergic nicotinic receptor complexes on outer hair cells. These findings are particularly promising because they provide a proof of principle supporting the enhancement of the medial olivocochlear system as a viable approach for prevention or treatment of age-related hearing loss. Therefore, it opens the way to the design of novel positive modulators of α9α10 nAChR receptors for clinical use in the prevention of both noise and age-related hearing loss.

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