Open AccessREM sleep stabilizes hypothalamic representation of feeding behavior
Author(s) -
Lukas T. Oesch,
Mary Gazea,
Thomas C. Gent,
Mojtaba Bandarabadi,
Carolina Gutierrez Herrera,
Antoine Adamantidis
Publication year - 2020
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1921909117
Subject(s) - sleep (system call) , neuroscience , inhibitory postsynaptic potential , eye movement , hypothalamus , lateral hypothalamus , biological neural network , feeding behavior , non rapid eye movement sleep , neuron , rapid eye movement sleep , psychology , biology , endocrinology , computer science , operating system
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LH vgat ) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LH vgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.
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