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Significance Enteric pathogens successfully colonize the host intestinal environment by regulating the expression of their metabolic and virulence genes. A high-throughput screen identified the arginine sensor ArgR as a regulator of virulence expression in enterohemorrhagicEscherichia coli . Here we show that ArgR senses arginine fluctuations and regulates the virulence of enterohemorrhagicE. coli andCitrobacter rodentium , both in vitro and during murine infections. Our work highlights the importance of gut metabolite sensing in affecting the disease outcome and vulnerability to pathogens.

l -Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens