l -Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens | Zendy

Zélia MenezesGarcia | Zendy; Aman Kumar | Zendy; Wenhan Zhu | Zendy; Sebastian Winter | Zendy; Vanessa Sperandio | Zendy

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l -Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens

Author(s) -

Zélia MenezesGarcia,

Aman Kumar,

Wenhan Zhu,

Sebastian Winter,

Vanessa Sperandio

Publication year - 2020

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1919683117

Subject(s) - virulence , citrobacter rodentium , biology , arginine , microbiology and biotechnology , effector , type three secretion system , pathogen , escherichia coli , arginine deiminase , secretion , gene , gene expression , genetics , amino acid , biochemistry

Significance Enteric pathogens successfully colonize the host intestinal environment by regulating the expression of their metabolic and virulence genes. A high-throughput screen identified the arginine sensor ArgR as a regulator of virulence expression in enterohemorrhagicEscherichia coli . Here we show that ArgR senses arginine fluctuations and regulates the virulence of enterohemorrhagicE. coli andCitrobacter rodentium , both in vitro and during murine infections. Our work highlights the importance of gut metabolite sensing in affecting the disease outcome and vulnerability to pathogens.

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