Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease | Zendy

Sumantra Chatterjee | Zendy; Priyanka Nandakumar | Zendy; Dallas R. Auer | Zendy; Stacey Gabriel | Zendy; Aravinda Chakravarti | Zendy

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Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease

Author(s) -

Sumantra Chatterjee,

Priyanka Nandakumar,

Dallas R. Auer,

Stacey Gabriel,

Aravinda Chakravarti

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1908756116

Subject(s) - neural crest , biology , enteric nervous system , mesenchyme , hirschsprung's disease , epithelium , microbiology and biotechnology , embryo , intestinal epithelium , embryogenesis , genetics , immunology , pathology , disease , neuroscience , medicine

Significance The mammalian gut is a complex set of tissues formed during development by orchestrating the timing of expression of many genes. Here we uncover the identity of these genes, their pathways, and how they change during gut organogenesis. We used RNA-seq profiling in the wild-type mouse gut in both sexes during development (E10.5–E14.5), as well as in aRet null mouse, a model of Hirschsprung disease (HSCR). These studies have allowed us to expand the universe of genes and developmental processes that contribute to enteric neuronal innervation and to its dysregulation in disease.

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