The MATH-BTB BPM3 and BPM5 subunits of Cullin3-RING E3 ubiquitin ligases target PP2CA and other clade A PP2Cs for degradation | Zendy

Jose Julian | Zendy; Alberto Coego | Zendy; Jorge LozanoJuste | Zendy; Esther Lechner | Zendy; Qian Wu | Zendy; Xu Zhang | Zendy; Ebe Merilo | Zendy; Borja BeldaPalazón | Zendy; SangYoul Park | Zendy; Sean R. Cutler | Zendy; Chengcai An | Zendy; Pascal Genschik | Zendy; Pedro L. Rodrı́guez | Zendy

Open Access

The MATH-BTB BPM3 and BPM5 subunits of Cullin3-RING E3 ubiquitin ligases target PP2CA and other clade A PP2Cs for degradation

Author(s) -

Jose Julian,

Alberto Coego,

Jorge LozanoJuste,

Esther Lechner,

Qian Wu,

Xu Zhang,

Ebe Merilo,

Borja BeldaPalazón,

SangYoul Park,

Sean R. Cutler,

Chengcai An,

Pascal Genschik,

Pedro L. Rodrı́guez

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1908677116

Subject(s) - ubiquitin , phosphatase , microbiology and biotechnology , abscisic acid , ubiquitin ligase , f box protein , protein subunit , protein degradation , chemistry , biochemistry , biology , phosphorylation , gene

Significance Relief of repression imposed by negative regulators is a crucial mechanism for plant hormone signaling. Clade A PP2Cs are key negative regulators of ABA signaling that are inhibited by ABA receptors. Degradation of PP2Cs is a complementary mechanism to PYR/PYL/RCAR-mediated ABA-dependent inhibition of PP2Cs. We reveal that BTB/POZ AND MATH DOMAIN proteins (BPMs), substrate adaptors of the multimeric cullin3 (CUL3)-RING-based E3 ligases (CRL3s), target PP2Cs for degradation. BPM-dependent degradation of PP2Cs is required for ABA-induced stomatal closure to counteract ABA-induced accumulation of PP2Cs and to reset resting phosphatase levels that allow efficient ABA signaling. Therefore, BPM-mediated proteolysis of transcription factors and clade A PP2Cs emerges as a general mechanism to regulate stress response and ABA signaling.

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