A packing for A-form DNA in an icosahedral virus | Zendy

Fengbin Wang | Zendy; Ying Liu | Zendy; Zhangli Su | Zendy; T. Osinski | Zendy; Guilherme A. P. de Oliveira | Zendy; James F. Conway | Zendy; Stefan Schouten | Zendy; Mart Krupovìč | Zendy; David Prangishvili | Zendy; Edward H. Egelman | Zendy

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A packing for A-form DNA in an icosahedral virus

Author(s) -

Fengbin Wang,

Ying Liu,

Zhangli Su,

T. Osinski,

Guilherme A. P. de Oliveira,

James F. Conway,

Stefan Schouten,

Mart Krupovìč,

David Prangishvili,

Edward H. Egelman

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1908242116

Subject(s) - icosahedral symmetry , sulfolobus , archaea , capsid , dna , biology , nucleoprotein , protein filament , bacteriophage , virus , biophysics , virology , crystallography , chemistry , genetics , bacteria , escherichia coli , gene

Significance Viruses need to package nucleic acid genomes so that the genetic material (either RNA or DNA) can survive outside of a cell and without the DNA repair that takes place within all cells. We have studied the structure of an icosahedral virus that infects a host living in nearly boiling acid. The outer capsid which covers the genome-containing membrane vesicle is composed of 2 proteins that have a variation of a previously observed fold. The genomic DNA is in the A-form first described for desiccated DNA, rather than the B-form more commonly found in biology. A-DNA may be the prevalent storage form of DNA in everything from bacterial spores to viruses inhabiting the most extreme environments.

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