Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species | Zendy

John W. Bostick | Zendy; Yetao Wang | Zendy; Zeli Shen | Zendy; Yong Ge | Zendy; Jeffrey B. Brown | Zendy; Zong-ming E. Chen | Zendy; Mansour Mohamadzadeh | Zendy; James G. Fox | Zendy; Liang Zhou | Zendy

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Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species

Author(s) -

John W. Bostick,

Yetao Wang,

Zeli Shen,

Yong Ge,

Jeffrey B. Brown,

Zong-ming E. Chen,

Mansour Mohamadzadeh,

James G. Fox,

Liang Zhou

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1908128116

Subject(s) - innate lymphoid cell , biology , helicobacter , immunology , gut flora , helicobacter pylori , inflammation , immunity , innate immune system , microbiology and biotechnology , immune system , genetics

Significance Innate lymphoid cells (ILCs) in the intestine maintain both defense against pathogens and homeostasis of intestinal tissue, which is exposed to environmental influences, including microbes and ingested foods. We identified a pair ofHelicobacter species that activate ILCs but negatively regulate proliferation of group 3 RORγt+ ILCs (ILC3s) that are important for host immunity and inflammation. This opens the door for future investigations that explore the molecular factors produced by microbes that may influence the maintenance of ILC3s in the intestine.

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