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Significance By performing a targeted genetic screen of temperature-sensitive mutations, this study identified 94 essentialSaccharomyces cerevisiae genome instability suppressing (eGIS) genes and 38 candidate eGIS genes. Analysis of The Cancer Genome Atlas data demonstrated that mutations in the human homologues of theS. cerevisiae eGIS genes were significantly enriched in 10 different human cancers. These results provide insights into the origin of genome instability in human cancers and provide tools for identifying and evaluating mutations that contribute to the development of cancer.

Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors